Beyond Medication: Integrating Spravato® and Ketamine-assisted therapy for lasting change
At Head Well- Integrative Psychiatry & Wellness, we know that true healing extends beyond symptom management. Many people living with depression, anxiety, or trauma feel they’ve “tried everything”—yet lasting relief remains elusive. Innovative treatments like Spravato® (esketamine) and ketamine-assisted psychotherapy (KAP) are changing that landscape, offering new ways to reconnect with hope and reclaim wellness.
By integrating cutting-edge neuroscience with compassionate, whole-person care, Head Well helps patients move from surviving to thriving—because wellness is within.
The New Era of Neuroplasticity-Based Healing
For decades, mental health treatment relied primarily on serotonin-based antidepressants. While helpful for many, they often leave others stuck in cycles of incomplete recovery. Both Spravato® and ketamine-assisted psychotherapy target a different neurotransmitter system—the glutamate pathway—to stimulate neuroplasticity, the brain’s natural ability to form new connections.
Increased brain-derived neurotrophic factor (BDNF) helps restore communication between mood and motivation networks, often relieving depressive symptoms within hours to days.
When combined with therapy, this period of neural “reset” becomes a powerful opportunity for emotional growth, behavioral change, and spiritual reconnection.
Spravato®: FDA-Approved Esketamine for Treatment-Resistant Depression
Spravato® is an FDA-approved nasal spray containing esketamine, a derivative of ketamine. Administered under medical supervision, it is specifically indicated for adults with treatment-resistant depression (TRD) or major depressive disorder with acute suicidal ideation.
At Head Well, Spravato® sessions take place in a calming, supportive environment. Patients rest comfortably while our clinical team monitors them, ensuring safety and comfort throughout the process.
Over time, Spravato® helps many patients achieve meaningful improvements in mood, energy, and motivation.
But we know medication alone is rarely enough. That’s why we emphasize integration—pairing Spravato®’s neurobiological effects with therapy, mindfulness, and lifestyle interventions to solidify and sustain healing.
Ketamine-Assisted Psychotherapy: Deep Healing Through Connection
While Spravato® primarily delivers pharmacologic benefits, ketamine-assisted psychotherapy (KAP) amplifies those effects through intentional therapeutic work. In KAP sessions, ketamine is administered in a setting designed to encourage introspection, guided by a therapist who helps patients explore insights and process emotional experiences.
This integrative model allows the medicine to open neurobiological “windows” of possibility, while psychotherapy helps patients translate those openings into sustainable change.
The benefits of KAP include:
• Deeper emotional insight and self-compassion
• Rapid relief from depression and anxiety
• Enhanced response to traditional therapy
• Improved connection—to self, others, and purpose
By weaving together medicine and meaning, KAP can help patients shift from coping to true transformation.
Why Integration Matters
At Head Well, we see Spravato® and KAP as complementary modalities within a broader integrative psychiatry framework. Combining biological, psychological, and lifestyle interventions maximizes outcomes and honors the complexity of each person’s experience.
Our integrative approach aims to identify the root causes and contributing factors of symptom presentation which may include:
• Testing and evaluation for metabolic, hormonal, and inflammatory imbalances
• Personalized life-style, nutrition and gut-brain health support
• Sleep, stress, and nervous system optimization
• Trauma-informed psychotherapy and mindfulness-based interventions
Healing doesn’t happen in isolation—it’s the product of a well-supported system working in harmony.
What to Expect at Head Well
Each patient’s path begins with a comprehensive assessment that explores the biological, psychological, and social dimensions of wellness. Together, we craft a precision treatment plan that may include Spravato®, KAP, or both, depending on your goals and needs.
During treatment, you’ll experience a blend of medical expertise and compassionate support. Our team guides you through each step—from preparation and dosing to integration and follow-up—ensuring that every experience moves you closer to balance and renewal.
FAQ
Is Spravato® the same as ketamine?
Spravato® contains esketamine, a specific form of the ketamine molecule, and is FDA-approved for treatment-resistant depression. KAP uses racemic ketamine, often delivered in a psychotherapeutic setting.
How quickly does it work?
Many people notice improvement after the first few sessions, as ketamine rapidly enhances neuroplasticity and mood regulation. Sustained results come from continued integration and support.
Is ketamine therapy safe?
When administered in a licensed medical environment under supervision, both Spravato® and ketamine therapy have strong safety records.
Wellness Is Within
Hope is not lost. Whether you’ve struggled with depression that hasn’t responded to medication, or you’re seeking deeper emotional healing, Head Well Integrative Psychiatry & Wellness offers evidence-informed, compassionate care designed to help you reconnect—with your mind, your body, and your purpose.
Discover how Spravato® and ketamine-assisted psychotherapy can unlock new pathways to healing.
👉 Schedule your consultation today. Wellness is within.